Caspase-10 Antibody| F42859-0.08ML/F42859-0.4ML/R30586

Caspase-10 Antibody| F42859-0.08ML/F42859-0.4ML/R30586 | Gentaur UK, US & Europe Distribution

Background: CASP10 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in the protein are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the Caspase-10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Caspase-10 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 164-192 from the human protein was used as the immunogen for this Caspase-10 antibody.

Storage: Aliquot the Caspase-10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A