Caspase-3 Antibody| F41376-0.08ML/F41376-0.4ML/R20270-0.1ML/R30358

Caspase-3 Antibody| F41376-0.08ML/F41376-0.4ML/R20270-0.1ML/R30358 | Gentaur UK, US & Europe Distribution

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Primate, Rabbit

Application: WB, IHC, FACS, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50

Application Note: Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Caspase-3 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 219-248 from the human protein was used as the immunogen for this Caspase-3 antibody.

Storage: Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A