Caspase-5 Antibody| F41059-0.08ML/F41059-0.4ML

Caspase-5 Antibody| F41059-0.08ML/F41059-0.4ML | Gentaur UK, US & Europe Distribution

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, FACS, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50

Application Note: Titration of the Caspase-5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Caspase-5 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 162-191 from the human protein was used as the immunogen for this Caspase-5 antibody.

Storage: Aliquot the Caspase-5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A