Cathepsin D (active, human) | 1022

Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.

1022 | Cathepsin D active human DataSheet

Biomolecule/Target: Cathepsin D

Synonyms: Cathepsin D (active, human)

Alternates names: Cathepsin D

Taglines: An active Lysosomal aspartyl protease

NCBI Gene ID #: 5909

NCBI Gene Symbol: RARRES2

Gene Source: Human

Accession #: Q99969

Recombinant: No

Source: Human liver

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): 365 units/mg

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: >300 units/mg protein. One unit is defined as the amount of enzyme that digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37°C. Substrate: acid denatured hemoglobin (0.2% in reaction mixture). Buffer: 100 mM formate. pH 3.3.

Molecular Weight: N/A

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from a solution containing 2 mM sodium phosphate, pH 6.5

Reconstitution Instructions: Reconstitute the vial in HO to a concentration of 0.1-1 µg/µl. Aliquot and refreeze at -80°C immediately for future use.

Amino acid sequence: N/A