CCR8 Antibody| F40687-0.08ML/F40687-0.4ML

CCR8 Antibody| F40687-0.08ML/F40687-0.4ML | Gentaur UK, US & Europe Distribution

Background: CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, FACS, ELISA

Application Details: Western blot: 1:1000, Flow Cytometry: 1:10-1:50

Application Note: Titration of the CCR8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CCR8 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 290-317 from the human protein was used as the immunogen for this CCR8 antibody.

Storage: Aliquot the CCR8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A