MCM8 Antibody| F45609-0.08ML/F45609-0.4ML/R32347

MCM8 Antibody| F45609-0.08ML/F45609-0.4ML/R32347 | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the MCM8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This MCM8 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 322-350 from the human protein was used as the immunogen for this MCM8 antibody.

Storage: Aliquot the MCM8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A