CD47 Polyclonal Antibody | E-AB-40365

CD47 Polyclonal Antibody | E-AB-40365 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Antigen identified by monoclonal antibody 1D8, Antigenic surface determinant protein OA3, CD 47, IAP, Integrin Associated Protein, Leukocyte surface antigen CD47, MER6, OA3, Protein MER6, Rh related antigen

Application: IHC

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Immunology

Background: CD47, also known as integrin-associated protein (IAP), is a member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. CD47 is heavily glycosylated and widely expressed by hematopoietic and nonhematopoietic cells. CD47 interacts with several membrane integrins and also acts a receptor for thrombospondin (THBS1). It is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. CD47 also functions as a ligand for signal regulatory protein-α (SIRPα). Upon binding CD47, SIRPα initiates a signaling cascade that results in the inhibition of phagocytosis.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Mouse Leukocyte surface antigen CD47 protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.3

Purification Method: Antigen Affinity Purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A