Description
CD95 Antibody [DX2] (APC) | 99-580 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human, Rhesus, African Green Monkey, Sooty Mangabey
Homology: N/A
Immunogen: Human CD95 transfected L cells
Research Area: Cancer, Cell Cycle, Immunology, Signal Transduction
Tested Application: Flow
Application: CD95 Antibody [DX2] for use in flow cytometry assays.
Specificiy: CD95
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [DX2]
Isotype: IgG1
Conjugate: APC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: Lot specific
Storage Condition: Store vial at 2-8˚C
Alternate Name: APO-1, Fas, TNFRSF6
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.