CDKN2B Antibody| F42340-0.08ML/F42340-0.4ML

CDKN2B Antibody| F42340-0.08ML/F42340-0.4ML | Gentaur UK, US & Europe Distribution

Background: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: IF, FACS, WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Flow Cytometry: 1:10-1:50

Application Note: Titration of the CDKN2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CDKN2B antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 102-130 from the human protein was used as the immunogen for this CDKN2B antibody.

Storage: Aliquot the CDKN2B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A