CDKN2C Antibody| F41067-0.08ML/F41067-0.4ML

CDKN2C Antibody| F41067-0.08ML/F41067-0.4ML | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the CDKN2C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CDKN2C antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 113-139 from the human protein was used as the immunogen for this CDKN2C antibody.

Storage: Aliquot the CDKN2C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A