Clinical Chemistry Anti-CCP Reagent Kit

The measurement of anti-CCP antibodies has become the method of choice in the accurate diagnosis of Rheumatoid Arthritis. Anti-CCP2 positivity can predict future development of RA in both asymptomatic individuals and in patients with undifferentiated arthritis.

Traditionally Anti-CCP testing has been performed using ELISA assays or on closed mainframe immunoassay analysers.

Now for the first time Anti-CCP testing can be performed on open chemistry systems using the new Axis-Shield Clinical Chemistry Anti-CCP kit.

Part Number: FHCCP100

Method: Latex Immunoassay

Description: Two liquid-stable reagents. Calibrator and control packs also available.

• Proven, reliable CCP2 technology
• CE-marked
• Excellent Clinical Specificity of >90%
• Low Total Imprecision

Intended Use

The Axis-Shield Anti-CCP test is a semi-quantitative assay for the detection of autoantibodies specific to cyclic citrullinated peptide (CCP) in either human serum or plasma specimens. Detection of anti-CCP antibodies is used as an aid in the diagnosis of Rheumatoid Arthritis (RA), and should be used in conjunction with other clinical information.  Autoantibody levels represent one parameter in a multi-criterion diagnostic process, encompassing both clinical and laboratory-based assessments.

Assay Principle

The determination of anti-CCP antibodies is based on a specific turbidimetric reaction which occurs between the antibodies present in the serum/plasma of patients affected by Rheumatoid Arthritis (RA) and highly purified synthetic cyclic citrullinated peptide coated on the surface of latex microparticles. Reaction occurs under optimal pH conditions and in the presence of an accelerator. The turbidity of the immune complex is proportional to the concentration of the analyte in the examined sample.