Description
COXII polyclonal Antibody | BS1653 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse
Application: WB
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: COXII polyclonal Antibody detects endogenous levels of COXII protein.
Molecular Weight: ~ 26 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cytochrome c oxidase polypeptide 2; Cytochrome c oxidase subunit 2; Cytochrome c oxidase subunit II; Cytochrome oxidase subunit 2; mt-Co2; Co2; COII; COX2; Cox2; COXII
Immunogen: A synthetic peptide corresponding to amino acids 49-63 of Mouse COXII.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: ErbB HER Signaling,