(DANRE) sh3bp4a Antibody (N-term) [APR32985G]

(DANRE) sh3bp4a Antibody (N-term) [APR32985G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Zf

Specificity: This DANRE sh3bp4a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 132-165 amino acids from the N-terminal region of DANRE sh3bp4a.

Cellular Localisation: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor- containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity) .

Molecular Weight: 108453

Clone: Polyclonal

Gene Name: sh3bp4a

Gene ID: 403082

Function: Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: SH3 domain-binding protein 4-A, sh3bp4a, sh3bp4