Dnmt3b Antibody| F40611-0.08ML/F40611-0.4ML/RQ6614

Dnmt3b Antibody| F40611-0.08ML/F40611-0.4ML/RQ6614 | Gentaur UK, US & Europe Distribution

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:2000, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Dnmt3b antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody.

Storage: Aliquot the Dnmt3b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A