Description
Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.
Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM).
1619 | Enzastaurin (LY317615) DataSheet
Alternate Name/Synonyms: LY317615, LY-317615, D04014
Appearance: Red-Orange Solid
Formulation: N/A
CAS Number: 170364-57-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₂H₂₉N₅O₂
Molecular Weight: 515.61
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO (5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A PKC beta inhibitor
MDL Number: MFCD11040980
PubChem CID: 176167
SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
InChi: InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31 (29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7- 15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
InChi Key: AXRCEOKUDYDWLF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
RT |
Shelf Life: |
24months |