Enzastaurin (LY317615) | 1619

Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM). Enz suppresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.

Enzastaurin (Enz) is a potent and selective inhibitor of PKCβ with antiproliferative activity (IC₅₀= ~6 nM).

1619 | Enzastaurin (LY317615) DataSheet

Alternate Name/Synonyms: LY317615, LY-317615, D04014

Appearance: Red-Orange Solid

Formulation: N/A

CAS Number: 170364-57-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₂₉N₅O₂

Molecular Weight: 515.61

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PKC beta inhibitor

MDL Number: MFCD11040980

PubChem CID: 176167

SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7

InChi: InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31 (29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7- 15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)

InChi Key: AXRCEOKUDYDWLF-UHFFFAOYSA-N