Description
A potent and selective inhibitor of histone methyltransferase EZH2. EPZ-6438 specifically inhibits cellular H3K27 methylation leading to selective apoptotic killing of SMARCB1 mutant MRT cells. It also induces neuronal differentiation and cell cycle inhibition while suppressing expression of Hedgehog (Hh) pathway genes.
EPZ-6438 is a potent and selective inhibitor of histone methyltransferase EZH2
Alternate Name/Synonyms: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; E-7438
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1403254-99-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₄H₄₄N₄O₄
Molecular Weight: 572.74
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A potent EZH2 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCOCC4)C=C3)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C2C
InChi: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChi Key: NSQSAUGJQHDYNO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |