Description
Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.
FAS inhibitor, C75 is an inhibitor of fatty acid synthase (FAS).
1547 | FAS Inhibitor, C75 DataSheet
Alternate Name/Synonyms: 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
Appearance: Off-white solid
Formulation: N/A
CAS Number: 191282-48-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₂₂O₄
Molecular Weight: 254.3
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (18 mg/ml)
Handling: Protect from light
Country of Origin: USA
Tag Line: A FAS inhibitor
MDL Number: MFCD03426157
PubChem CID: 9881506
SMILES: CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
InChi: InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
InChi Key: VCWLZDVWHQVAJU-NEPJUHHUSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
RT |
Shelf Life: |
24months |