FAS Inhibitor, C75 | 1547

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

FAS inhibitor, C75 is an inhibitor of fatty acid synthase (FAS).

1547 | FAS Inhibitor, C75 DataSheet

Alternate Name/Synonyms: 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

Appearance: Off-white solid

Formulation: N/A

CAS Number: 191282-48-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₂₂O₄

Molecular Weight: 254.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (18 mg/ml)

Handling: Protect from light

Country of Origin: USA

Tag Line: A FAS inhibitor

MDL Number: MFCD03426157

PubChem CID: 9881506

SMILES: CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O

InChi: InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1

InChi Key: VCWLZDVWHQVAJU-NEPJUHHUSA-N