Description
Cell-permeable. Blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins). Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Prevents increases in body weight, blood glucose and hepatic fat accumulation in obese ob/ob mice.
Fatostatin blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins). Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP).
Alternate Name/Synonyms: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Appearance: Yellow solid
Formulation: N/A
CAS Number: 298197-04-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₈N₂S
Molecular Weight: 294.41
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO ( 25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Sterol Regulatory Binding Proteins (SREBPs) inhibitor
MDL Number: MFCD00760867
PubChem CID: 1889993
SMILES: CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C
InChi: InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
InChi Key: ZROSUBKIGBSZCG-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |