FG-4592 | 9681

FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.

FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.

9681 | FG-4592 DataSheet

Alternate Name/Synonyms: N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine; ASP1517; Roxadustat

Appearance: Wite to off-white solid

Formulation: N/A

CAS Number: 808118-40-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆N₂O₅

Molecular Weight: 352.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor

MDL Number: N/A

PubChem CID: 11256664

SMILES: CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O

InChi: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)

InChi Key: YOZBGTLTNGAVFU-UHFFFAOYSA-N