Description
FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.
FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.
Alternate Name/Synonyms: N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine; ASP1517; Roxadustat
Appearance: Wite to off-white solid
Formulation: N/A
CAS Number: 808118-40-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₆N₂O₅
Molecular Weight: 352.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor
MDL Number: N/A
PubChem CID: 11256664
SMILES: CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
InChi: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
InChi Key: YOZBGTLTNGAVFU-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |