Description
Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC₅₀ of 2.5 µM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC₅₀ values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 μM, 0.72 μM, 5.51 μM and 1.51 μM, respectively.
Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC₅₀ of 2.5 µM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC₅₀ values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 μM, 0.72 μM, 5.51 μM and 1.51 μM, respectively.
B2955 | Flubendazole DataSheet
Alternate Name/Synonyms: methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate; Flumoxane; Fluvermal; Flubendazol; fluoromebendazole; Flubenol; Flubendazolum; Flumoxal; Flumoxanal; Flutelmium; NSC 313680
Appearance: Solid
Formulation:
CAS Number: 31430-15-6
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₆H₁₂FN₃O₃
Molecular Weight: 313.28
Cell-Permeable?: True
Purity: 99.7%
Solubilities: ~1 mg/ml in ethanol, DMSO and water in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent anthelmintic agent
MDL Number: MFCD00871999
PubChem CID: 35802
SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=C(C=C3)F
InChi: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)
InChi Key: CPEUVMUXAHMANV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36months |