Flubendazole | B2955

Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC₅₀ of 2.5 µM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC₅₀ values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 μM, 0.72 μM, 5.51 μM and 1.51 μM, respectively.

Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. It disrupts tubulin polymerization by showing preference for binding to nematode tubulin rather than the tubulin in host. Flubendazole inhibits mammalian tubulin polymerization with an IC₅₀ of 2.5 µM. The microtubule-disrupting properties of benzimidazoles cause potential anti-cancer activity. The IC₅₀ values for inhibition of proliferation of MDA-MB-231, BT-549, MCF-7 and SK-BR-3 cells are 1.75 μM, 0.72 μM, 5.51 μM and 1.51 μM, respectively.

B2955 | Flubendazole DataSheet

Alternate Name/Synonyms: methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate; Flumoxane; Fluvermal; Flubendazol; fluoromebendazole; Flubenol; Flubendazolum; Flumoxal; Flumoxanal; Flutelmium; NSC 313680

Appearance: Solid

Formulation:

CAS Number: 31430-15-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₆H₁₂FN₃O₃

Molecular Weight: 313.28

Cell-Permeable?: True

Purity: 99.7%

Solubilities: ~1 mg/ml in ethanol, DMSO and water in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent anthelmintic agent

MDL Number: MFCD00871999

PubChem CID: 35802

SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=C(C=C3)F

InChi: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

InChi Key: CPEUVMUXAHMANV-UHFFFAOYSA-N