Description
Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved in hepatocarcinogenesis, thereby making it an attractive therapy for hepatocellular carcinoma.
Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved in hepatocarcinogenesis, thereby making it an attractive therapy for hepatocellular carcinoma.
9459 | Ganetespib (STA-9090) DataSheet
Alternate Name/Synonyms: 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H- 1,2,4-triazol-3-one
Appearance: Off-white solid
Formulation: N/A
CAS Number: 888216-25-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₀H₂₀N₄O₃
Molecular Weight: 364.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, Hsp90 inhibitor
MDL Number: MFCD22420818
PubChem CID: 23624255
SMILES: CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O
InChi: InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,21,25H,1-3H3,(H,22,27)/b19-15+
InChi Key: MWTUOSWPJOUADP-XDJHFCHBSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |