Ganetespib (STA-9090) | 9459

Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved in hepatocarcinogenesis, thereby making it an attractive therapy for hepatocellular carcinoma.

Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved in hepatocarcinogenesis, thereby making it an attractive therapy for hepatocellular carcinoma.

9459 | Ganetespib (STA-9090) DataSheet

Alternate Name/Synonyms: 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H- 1,2,4-triazol-3-one

Appearance: Off-white solid

Formulation: N/A

CAS Number: 888216-25-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₀N₄O₃

Molecular Weight: 364.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, Hsp90 inhibitor

MDL Number: MFCD22420818

PubChem CID: 23624255

SMILES: CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O

InChi: InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,21,25H,1-3H3,(H,22,27)/b19-15+

InChi Key: MWTUOSWPJOUADP-XDJHFCHBSA-N