26
GCK (Glucokinase) Antibody | 3154
- SKU:
- 26-3154-100-GEN
- Availability:
- Usually shipped in 5 working days
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
3154 | GCK (Glucokinase) Antibody DataSheet
Antibody Target: GCK (Glucokinase)
Target Alternative Name: Hexokinase D, Hexokinase type IV, HK IV, HK4, Glucokinase
Tag Line:
Category: GCK
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human, mouse
Immunogen Sequence: Synthetic peptide selected from the C-terminal region of human GCK
Accession #: P35557
Gene ID: 2645
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.25 mg/ml
Formulation: 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification: Affinity purified
Application: ELISA, Western blot, Immunohistochemistry
Positive Control:
Application And Usages: The antibody can be used for ELISA (0.25 µg/ml), Western Blotting (0.5 2.5 µg/ml) and Immunohistochemistry (2.5 5.0 µg/ml).
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Not Verified
Additional Information
Size: |
100 ug |
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |