GCK (Glucokinase) Antibody | 3154

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

3154 | GCK (Glucokinase) Antibody DataSheet

Antibody Target: GCK (Glucokinase)

Target Alternative Name: Hexokinase D, Hexokinase type IV, HK IV, HK4, Glucokinase

Tag Line:

Category: GCK

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human, mouse

Immunogen Sequence: Synthetic peptide selected from the C-terminal region of human GCK

Accession #: P35557

Gene ID: 2645

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.25 mg/ml

Formulation: 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity purified

Application: ELISA, Western blot, Immunohistochemistry

Positive Control:

Application And Usages: The antibody can be used for ELISA (0.25 µg/ml), Western Blotting (0.5 – 2.5 µg/ml) and Immunohistochemistry (2.5 – 5.0 µg/ml).

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified:

ELISA Verified: Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified