Description
Gilteritinib is a potent FLT3 (FMS-like tyrosine kinase 3) inhibitor which shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
Gilteritinib is a potent FLT3 (FMS-like tyrosine kinase 3) inhibitor which shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
B1294 | Gilteritinib DataSheet
Alternate Name/Synonyms: 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; ASP 2215
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1254053-43-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₉H₄₄N₈O₃
Molecular Weight: 552.71
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent FLT3 (FMS-like tyrosine kinase 3) inhibitor
MDL Number: N/A
PubChem CID: 49803313
SMILES: CCC1=NC(=C(N=C1NC2CCOCC2)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC)C(=O)N
InChi: InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)
InChi Key: GYQYAJJFPNQOOW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |