Gilteritinib | B1294

Gilteritinib is a potent FLT3 (FMS-like tyrosine kinase 3) inhibitor which shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.

Gilteritinib is a potent FLT3 (FMS-like tyrosine kinase 3) inhibitor which shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.

B1294 | Gilteritinib DataSheet

Alternate Name/Synonyms: 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; ASP 2215

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1254053-43-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₄₄N₈O₃

Molecular Weight: 552.71

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent FLT3 (FMS-like tyrosine kinase 3) inhibitor

MDL Number: N/A

PubChem CID: 49803313

SMILES: CCC1=NC(=C(N=C1NC2CCOCC2)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC)C(=O)N

InChi: InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

InChi Key: GYQYAJJFPNQOOW-UHFFFAOYSA-N