GLPG0634 Analog | B1836

GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.

B1836 | GLPG0634 Analog DataSheet

Alternate Name/Synonyms: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide; GLP-0634

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1206101-20-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₁₈N₆O₂

Molecular Weight: 410.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK1 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2

InChi: InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)

InChi Key: QZXABVVSCDZCLR-UHFFFAOYSA-N