Description
GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
B1836 | GLPG0634 Analog DataSheet
Alternate Name/Synonyms: N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide; GLP-0634
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1206101-20-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₃H₁₈N₆O₂
Molecular Weight: 410.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective JAK1 inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2
InChi: InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
InChi Key: QZXABVVSCDZCLR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |