Description
GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC₅₀ values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines.
GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC₅₀ values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines.
Alternate Name/Synonyms: (S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one, GNE272
Appearance: Crystalline solid
Formulation:
CAS Number: 1936428-93-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₅FN₆O₂
Molecular Weight: 424.48
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >100 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective probe for the Bromodomains of CBP/EP300
MDL Number:
PubChem CID: 121372887
SMILES: CC(=O)N1CCC2=C(C1)C(=NN2C3CCOC3)NC4=C(C=C(C=C4)C5=CN(N=C5)C)F
InChi: InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/m0/s1
InChi Key: NKOJNOBJGYTLLZ-KRWDZBQOSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |