GNE-272 | B2533

GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC₅₀ values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines.

GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC₅₀ values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines.

B2533 | GNE-272 DataSheet

Alternate Name/Synonyms: (S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one, GNE272

Appearance: Crystalline solid

Formulation:

CAS Number: 1936428-93-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅FN₆O₂

Molecular Weight: 424.48

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >100 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective probe for the Bromodomains of CBP/EP300

MDL Number:

PubChem CID: 121372887

SMILES: CC(=O)N1CCC2=C(C1)C(=NN2C3CCOC3)NC4=C(C=C(C=C4)C5=CN(N=C5)C)F

InChi: InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/m0/s1

InChi Key: NKOJNOBJGYTLLZ-KRWDZBQOSA-N