Description
GNF-4877 is a potent inhibitor of Dyrk1a (IC₅₀ = 6 nM) and GSK-3β (IC₅₀ = 16 nM), that promotes pancreatic β cell proliferation in rodent and human primary islets.
GNF-4877 is a potent inhibitor of Dyrk1a (IC₅₀ = 6 nM) and GSK-3β (IC₅₀ = 16 nM), that promotes pancreatic β cell proliferation in rodent and human primary islets.
Alternate Name/Synonyms: GNF4877,(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid
Appearance: Pale yellow to dark orange solid
Formulation:
CAS Number: 2041073-22-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₇FN₆O₄
Molecular Weight: 494.52
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~2 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent DYRK1A and GSK3β inhibitor
MDL Number:
PubChem CID: 139600315
SMILES: CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCCC(C4)C(=O)O)N
InChi: InChI=1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8,10-12,14-15H,3-4,9,13H2,1-2H3,(H2,27,29)(H,31,33)(H,34,35)/t15-/m1/s1
InChi Key: UZIATSFXNVOVFE-OAHLLOKOSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |