GNF-4877 | B2720

GNF-4877 is a potent inhibitor of Dyrk1a (IC₅₀ = 6 nM) and GSK-3β (IC₅₀ = 16 nM), that promotes pancreatic β cell proliferation in rodent and human primary islets.

GNF-4877 is a potent inhibitor of Dyrk1a (IC₅₀ = 6 nM) and GSK-3β (IC₅₀ = 16 nM), that promotes pancreatic β cell proliferation in rodent and human primary islets.

B2720 | GNF-4877 DataSheet

Alternate Name/Synonyms: GNF4877,(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid

Appearance: Pale yellow to dark orange solid

Formulation:

CAS Number: 2041073-22-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₇FN₆O₄

Molecular Weight: 494.52

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~2 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent DYRK1A and GSK3β inhibitor

MDL Number:

PubChem CID: 139600315

SMILES: CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCCC(C4)C(=O)O)N

InChi: InChI=1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8,10-12,14-15H,3-4,9,13H2,1-2H3,(H2,27,29)(H,31,33)(H,34,35)/t15-/m1/s1

InChi Key: UZIATSFXNVOVFE-OAHLLOKOSA-N