GS-441524 | B3076

GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays against HCV, YFV, DENV-2, Influenza A, Parainfluenza 3 and SARS-CoV viruses with EC₅₀ values ranging from 1.7 μM-27.9 μM. It inhibits SARS-CoV and MERS-CoV infected human airway epithelial cell cultures with EC₅₀ values of 0.18 μM and 0.86 μM respectively. GS-441524 is suggested for the treatment of COVID-19 due to lower toxicity and simpler synthesis when compared to remdesivir.

GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays against HCV, YFV, DENV-2, Influenza A, Parainfluenza 3 and SARS-CoV viruses with EC₅₀ values ranging from 1.7 μM-27.9 μM. It inhibits SARS-CoV and MERS-CoV infected human airway epithelial cell cultures with EC₅₀ values of 0.18 μM and 0.86 μM respectively. GS-441524 is suggested for the treatment of COVID-19 due to lower toxicity and simpler synthesis when compared to remdesivir.

B3076 | GS-441524 DataSheet

Alternate Name/Synonyms: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile; (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile; EVO984; 2-C-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivir metabolite

Appearance: Off-white to light yellow solid powder

Formulation:

CAS Number: 1191237-69-0

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₂H₁₃N₅O₄

Molecular Weight: 291.26

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~10 mg/ml in DMSO and DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A metabolite of remdesivir with antiviral activity

MDL Number:

PubChem CID: 44468216

SMILES: C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N

InChi: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1

InChi Key: BRDWIEOJOWJCLU-LTGWCKQJSA-N