Description
GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays against HCV, YFV, DENV-2, Influenza A, Parainfluenza 3 and SARS-CoV viruses with EC₅₀ values ranging from 1.7 μM-27.9 μM. It inhibits SARS-CoV and MERS-CoV infected human airway epithelial cell cultures with EC₅₀ values of 0.18 μM and 0.86 μM respectively. GS-441524 is suggested for the treatment of COVID-19 due to lower toxicity and simpler synthesis when compared to remdesivir.
GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays against HCV, YFV, DENV-2, Influenza A, Parainfluenza 3 and SARS-CoV viruses with EC₅₀ values ranging from 1.7 μM-27.9 μM. It inhibits SARS-CoV and MERS-CoV infected human airway epithelial cell cultures with EC₅₀ values of 0.18 μM and 0.86 μM respectively. GS-441524 is suggested for the treatment of COVID-19 due to lower toxicity and simpler synthesis when compared to remdesivir.
Alternate Name/Synonyms: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile; (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile; EVO984; 2-C-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivir metabolite
Appearance: Off-white to light yellow solid powder
Formulation:
CAS Number: 1191237-69-0
Structure Available?: TRUE
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₁₂H₁₃N₅O₄
Molecular Weight: 291.26
Cell-Permeable?: TRUE
Purity: >98%
Solubilities: ~10 mg/ml in DMSO and DMF
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A metabolite of remdesivir with antiviral activity
MDL Number:
PubChem CID: 44468216
SMILES: C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N
InChi: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
InChi Key: BRDWIEOJOWJCLU-LTGWCKQJSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |