GSK-J5 (hydrochloride) | B2841

GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that depends on both JMJD3 and UTX. GSK-J5 is a weak inhibitor of JMJD3.

GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that depends on both JMJD3 and UTX. GSK-J5 is a weak inhibitor of JMJD3.

B2841 | GSK-J5 (hydrochloride) DataSheet

Alternate Name/Synonyms: N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, ethyl ester, monohydrochoride; ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride

Appearance: A crystalline solid

Formulation:

CAS Number: 1797983-32-4

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₄H₂₈ClN₅O₂

Molecular Weight: 454

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~20 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An isomer of GSK-J4 and a prodrug for neagtive control GSK-J2

MDL Number:

PubChem CID: 126456082

SMILES: CCOC(=O)CCNC1=CC(=NC(=N1)C2=CN=CC=C2)N3CCC4=CC=CC=C4CC3.Cl

InChi: InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29;/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28);1H

InChi Key: QQHQMHJAOKADED-UHFFFAOYSA-N