Description
GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that depends on both JMJD3 and UTX. GSK-J5 is a weak inhibitor of JMJD3.
GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that depends on both JMJD3 and UTX. GSK-J5 is a weak inhibitor of JMJD3.
B2841 | GSK-J5 (hydrochloride) DataSheet
Alternate Name/Synonyms: N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, ethyl ester, monohydrochoride; ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride
Appearance: A crystalline solid
Formulation:
CAS Number: 1797983-32-4
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₂₄H₂₈ClN₅O₂
Molecular Weight: 454
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~20 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An isomer of GSK-J4 and a prodrug for neagtive control GSK-J2
MDL Number:
PubChem CID: 126456082
SMILES: CCOC(=O)CCNC1=CC(=NC(=N1)C2=CN=CC=C2)N3CCC4=CC=CC=C4CC3.Cl
InChi: InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29;/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28);1H
InChi Key: QQHQMHJAOKADED-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Dry Ice |
Shelf Life: |
36 months |