Description
GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.
GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.
Alternate Name/Synonyms: 1-[4-chloro-2-hydroxy-3-[(3S)-piperidin-3-yl]sulfonylphenyl]-3-(3-fluoro-2-methylphenyl)urea; Danirixin
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 954126-98-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₁ClFN₃O₄S
Molecular Weight: 441.9
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (> 8 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: GSK1325756 is selective and reversible CXCR2 antogonist
MDL Number:
PubChem CID: 24780598
SMILES: CC1=C(C=CC=C1F)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)C3CCCNC3)O
InChi: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1
InChi Key: NGYNBSHYFOFVLS-LBPRGKRZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |