GSK1325756 | B1103

GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.

GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.

B1103 | GSK1325756 DataSheet

Alternate Name/Synonyms: 1-[4-chloro-2-hydroxy-3-[(3S)-piperidin-3-yl]sulfonylphenyl]-3-(3-fluoro-2-methylphenyl)urea; Danirixin

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 954126-98-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₁ClFN₃O₄S

Molecular Weight: 441.9

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: GSK1325756 is selective and reversible CXCR2 antogonist

MDL Number:

PubChem CID: 24780598

SMILES: CC1=C(C=CC=C1F)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)C3CCCNC3)O

InChi: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1

InChi Key: NGYNBSHYFOFVLS-LBPRGKRZSA-N