GSK2578215A | 2845

GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases. GSK2578215A displays good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.

GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases

2845 | GSK2578215A DataSheet

Alternate Name/Synonyms: 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide

Appearance: White solid

Formulation: N/A

CAS Number: 1285515-21-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₈FN₃O₂

Molecular Weight: 399.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Apotent and selective LRRK2 inhibitor

MDL Number: N/A

PubChem CID: 68107965

SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

InChi: InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)

InChi Key: WCIGMFCFPXZRMQ-UHFFFAOYSA-N