Description
GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases. GSK2578215A displays good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.
GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases
Alternate Name/Synonyms: 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
Appearance: White solid
Formulation: N/A
CAS Number: 1285515-21-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₁₈FN₃O₂
Molecular Weight: 399.42
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Apotent and selective LRRK2 inhibitor
MDL Number: N/A
PubChem CID: 68107965
SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4
InChi: InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
InChi Key: WCIGMFCFPXZRMQ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |