Description
GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF.
GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity.
2417 | GW 4869 dihydrocloride DataSheet
Alternate Name/Synonyms: 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-propenamide, dihydrochloride; GW69A; GW554869A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 6823-69-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₂₈N₆O₂ · 2HCl [xH₂O]
Molecular Weight: 577.5
Cell-Permeable?: Yes
Purity: ≥90%
Solubilities: DMSO (~0.2 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A non-competitive inhibitor of neutral sphingomyelinases
MDL Number: N/A
PubChem CID: 16078967
SMILES: C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5=
InChi: InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;;
InChi Key: NSFKAZDTKIKLKT-CLEIDKRQSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |