GW 4869 dihydrocloride | 2417

GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF.

GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity.

2417 | GW 4869 dihydrocloride DataSheet

Alternate Name/Synonyms: 3,​3'-​(1,​4-​phenylene)bis[N-​[4-​(4,​5-​dihydro-​1H-​imidazol-​2-​yl)phenyl]-​2-​propenamide, dihydrochloride; GW69A; GW554869A

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 6823-69-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₂₈N₆O₂ · 2HCl [xH₂O]

Molecular Weight: 577.5

Cell-Permeable?: Yes

Purity: ≥90%

Solubilities: DMSO (~0.2 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A non-competitive inhibitor of neutral sphingomyelinases

MDL Number: N/A

PubChem CID: 16078967

SMILES: C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5=

InChi: InChI=1S/C30H28N6O2.2ClH/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;;/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*1H/b15-5+,16-6+;;

InChi Key: NSFKAZDTKIKLKT-CLEIDKRQSA-N