Description
HA14-1 is a potent, cell-permeable Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
HA14-1 is a potent, cell-permeable Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. Also binds to the antiapoptotic Blc-2 proteins Bcl-XL and Bcl-w.
Alternate Name/Synonyms: 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Appearance: White solid
Formulation: N/A
CAS Number: 65673-63-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₇H₁₇BrN₂O₅
Molecular Weight: 409.23
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>35 mg/ml) or EtOH (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, cell-permeable Bcl-2 inhibitor with potential anticancer activity.
MDL Number: MFCD00218213
PubChem CID: 3549
SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
InChi: InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChi Key: SXJDCULZDFWMJC-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |