HBS1L Antibody (Center) [APR16672G]

HBS1L Antibody (Center) [APR16672G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This HBS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 460-486 amino acids from the Central region of human HBS1L.

Cellular Localisation: [Isoform 2]: Cytoplasm

Molecular Weight: 75473

Clone: Polyclonal

Gene Name: HBS1L

Gene ID: 10767

Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132) . In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132) . Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132) .

Summary: Tissue Location: Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: HBS1-like protein, ERFS, HBS1L, HBS1, KIAA1038