LBD
HBS1L Antibody (Center) [APR16672G]
- SKU:
- LBD-APR16672G
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Description
HBS1L Antibody (Center) [APR16672G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This HBS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 460-486 amino acids from the Central region of human HBS1L.
Cellular Localisation: [Isoform 2]: Cytoplasm
Molecular Weight: 75473
Clone: Polyclonal
Gene Name: HBS1L
Gene ID: 10767
Function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132) . In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132) . Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132) .
Summary: Tissue Location: Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: HBS1-like protein, ERFS, HBS1L, HBS1, KIAA1038