Hepatocyte Growth Factor Antibody (HGF)| F40371-0.08ML/V7839-100UG/V7839-20UG

Hepatocyte Growth Factor Antibody (HGF)| F40371-0.08ML/V7839-100UG/V7839-20UG | Gentaur UK, US & Europe Distribution

Background: Hepatocyte Growth Factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 64-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq].

Format: Purified

Clone: 489CT6.12.6

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:100-1:250

Application Note: Titration of the HGF antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This HGF antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 521-554 from the human protein was used as the immunogen for this HGF antibody.

Storage: Aliquot the HGF antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A